The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains
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چکیده
منابع مشابه
The mouse antibody heavy chain repertoire is germline-focused and highly variable between inbred strains.
The human and mouse antibody repertoires are formed by identical processes, but like all small animals, mice only have sufficient lymphocytes to express a small part of the potential antibody repertoire. In this study, we determined how the heavy chain repertoires of two mouse strains are generated. Analysis of IgM- and IgG-associated VDJ rearrangements generated by high-throughput sequencing c...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2015
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2014.0236